The Duke’s quest connects to the Queensbury Crypt boss, so it carries a story spoiler.
The Duke is a timid NPC — “a lover, not a fighter” — who can be found wandering Queensbury Crypt in search of a mysterious, lost love.

Escort the Duke to his casket and he gives you the Proto Spark, one of the best trinkets in the game — it grants one free save from death. His lost love is tied to the crypt’s boss, The Duchess of Queensbury, giving the whole quest an implied tragic story at its core.